Y.Takeda - Integrated Vision Research Center

Yukari Takeda 生命科学部 生命情報学科 助教

Yukari Takeda

Research theme

  1. 膵β細胞におけるGLP-1受容体刺激によるインスリン分泌増強作用の理論解析

  2. Theoretical analysis of the mechanisms underlying the insulinotropic effect of glucagon-like peptide-1 (GLP-1) in pancreatic beta-cells.
    A gastrointestinal hormone, GLP-1, increases [cAMP] and synergistically enhances glucose-stimulated insulin secretion (GSIS) in pancreatic beta cells. However, the mechanisms underlying the secretagogue action of GLP-1 have not been clearly elucidated due to involvement of complex interactions among multiple cellular factors. Based on the experimental findings, we thus adopt a strategy of developing mathematical models and perform simulation studies and theoretical analyses to evaluate the quantitative mechanisms underlying the GLP-1-induced increase in membrane excitability and dynamic Ca2+ mobilization, which in turn facilitate GSIS in pancreatic β-cells.

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